Sylvatic Dengue Virus Type 2 Activity in Humans, Nigeria, 1966
Author Information
Author(s): Vasilakis Nikos, Tesh Robert B., Weaver Scott C.
Primary Institution: University of Texas Medical Branch
Hypothesis
Unrecognized spillover epidemics may be caused by sylvatic DENV-2 strains in West Africa.
Conclusion
The identification of sylvatic DENV-2 strains from febrile patients suggests the first documented outbreak of sylvatic DENV-2 in humans.
Supporting Evidence
- Sylvatic DENV strains are considered the evolutionary progenitors of endemic strains.
- Only sylvatic DENV-2 has been identified in West Africa.
- Three sylvatic DENV-2 isolates were obtained from febrile patients in Nigeria.
Takeaway
Scientists found a type of dengue virus in sick people in Nigeria that usually lives in forests, showing it can make people sick too.
Methodology
Phylogenetic analysis of complete virus genomes from human isolates obtained in Nigeria.
Potential Biases
Potential biases due to limited access to healthcare and diagnostics.
Limitations
Limited availability of reliable epidemiologic information and inability to differentiate between urban and sylvatic DENV-2 infection.
Participant Demographics
Patients ranged from 3 months to 38 years of age.
Digital Object Identifier (DOI)
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