Reproductive Factors and Colorectal Cancer Risk
Author Information
Author(s): Yoo K-Y, Tajima K, Inoue M, Takezaki T, Hirose K, Hamajima N, Park S K, Kang D H, Kato T, Hirai T
Primary Institution: Seoul National University College of Medicine
Hypothesis
Reproductive factors of colorectal cancer, which are probably mediated by endogenous hormones, would differ according to colonic subsite.
Conclusion
The study found that certain reproductive factors are significantly associated with the risk of colorectal cancer, particularly for distal colon cancer compared to proximal colon cancer.
Supporting Evidence
- Late age at interview was significantly associated with colorectal cancer risk.
- Family history of colorectal cancer among first-degree relatives was a risk factor.
- Menstrual regularity was linked to colorectal cancer risk.
- Late age at menopause was associated with increased risk.
- Late age at first pregnancy was significantly related to colorectal cancer risk.
- Late age at first full-term pregnancy was a significant risk factor.
- Odds ratios for age at menarche were significantly higher for distal than proximal colon cancer.
Takeaway
This study looked at how things like age at first pregnancy can affect the risk of getting colon cancer, and found that these factors matter differently for different parts of the colon.
Methodology
Information on reproductive factors was obtained from female colorectal cancer cases and cancer-free controls, followed by multiple logistic analysis.
Participant Demographics
372 female colorectal cancer cases and 31,061 cancer-free controls.
Statistical Information
P-Value
P = 0.016 for age at first pregnancy; P = 0.028 for age at first full-term pregnancy.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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