Immune Recognition of the 60kD Heat Shock Protein and Its Impact on Fertility
Author Information
Author(s): Steven S. Witkin, Jan Jeremias, Andreas Neuer, Sami David, Isaac Kligman, Miklos Toth, Emily Willner, Keren Witkin
Primary Institution: Cornell University Medical College and Mount Sinai Medical Center
Hypothesis
Does immune sensitization to the 60kD heat shock protein affect pregnancy outcomes in women?
Conclusion
Women sensitized to the 60kD heat shock protein have poorer pregnancy outcomes compared to those who are not sensitized.
Supporting Evidence
- The presence of cervical IgA antibodies to hsp60 correlated with implantation failure after embryo transfer.
- Women with a history of primary infertility had a higher prevalence of cervical anti-hsp60 IgA.
- Cervical anti-hsp60 IgA correlated with pro-inflammatory cytokines in the cervix.
- Women with a history of two or more consecutive first trimester spontaneous abortions had a higher prevalence of IgG antibodies to hsp60.
Takeaway
Some women have an immune response to a protein that can affect their ability to get pregnant, especially if they have had certain infections.
Methodology
The study analyzed cervical and serum samples from women undergoing IVF and those with infertility to assess the presence of antibodies to hsp60.
Potential Biases
Potential bias in sample selection and self-reported infertility history.
Limitations
The study may not account for all factors affecting fertility and relies on specific populations of women.
Participant Demographics
Women of reproductive age, including those undergoing IVF and those with unexplained infertility.
Statistical Information
P-Value
p<0.003
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website