Breast Conservation Rates for Large Invasive Carcinomas
Author Information
Author(s): Bollet M A, Savignoni A, Pierga J-Y, Lae M, Fourchotte V, Kirova Y M, Dendale R, Campana F, Sigal-Zafrani B, Salmon R, Fourquet A, Vincent-Salomon A
Primary Institution: Institut Curie
Hypothesis
This study aims to compare the outcome of lobular vs ductal carcinomas after neoadjuvant chemotherapy.
Conclusion
Lobular carcinomas show a lower response rate to neoadjuvant chemotherapy than ductal carcinomas, but the lobular type does not adversely affect locoregional control or overall survival.
Supporting Evidence
- Clinical response to primary chemotherapy was significantly worse for lobular than for ductal carcinomas (47% vs 60%).
- Breast conservation rates were high for both ductal and lobular carcinomas (65% and 54%, respectively).
- Lobular carcinomas had no adverse effect on locoregional control or overall survival.
Takeaway
This study looked at how well two types of breast cancer respond to treatment. It found that lobular cancer doesn't respond as well to chemotherapy as ductal cancer, but both types had good chances of keeping their breasts.
Methodology
Patients with clinical stage II/IIIA ductal or lobular invasive breast carcinomas were treated with primary anthracycline-based polychemotherapy followed by either breast conservation or mastectomy.
Potential Biases
Potential selection bias due to the retrospective nature of the study.
Limitations
The study is retrospective and may not account for all variables influencing treatment outcomes.
Participant Demographics
Patients included 672 with ductal and 78 with lobular invasive breast carcinomas, with lobular patients being significantly older.
Statistical Information
P-Value
0.04
Confidence Interval
95% CI, 62–70%
Statistical Significance
p=0.04
Digital Object Identifier (DOI)
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