Genetic Study of Subclinical Atherosclerosis in the Framingham Heart Study
Author Information
Author(s): O'Donnell Christopher J, Cupples L Adrienne, D'Agostino Ralph B, Fox Caroline S, Hoffmann Udo, Hwang Shih-Jen, Ingellson Erik, Liu Chunyu, Murabito Joanne M, Polak Joseph F, Wolf Philip A, Demissie Serkalem
Primary Institution: The National Heart, Lung, and Blood Institute's Framingham Heart Study
Hypothesis
What genetic variants are associated with subclinical atherosclerosis measurements?
Conclusion
The study identified several SNPs that may be associated with subclinical atherosclerosis phenotypes, but none met the criteria for genome-wide significance.
Supporting Evidence
- The study genotyped over 100,000 SNPs in 1345 subjects.
- Associations were evaluated using linear regression and family-based association testing.
- The study identified 11 SNPs with p < 10-5 by GEE and five SNPs with p < 10-5 by FBAT.
Takeaway
Scientists looked at people's genes to see if they could find links to heart problems that aren't obvious yet. They found some clues but need to check them again.
Methodology
The study genotyped over 100,000 SNPs in 1345 subjects and analyzed associations with various subclinical atherosclerosis phenotypes using linear regression and family-based association testing.
Limitations
The findings did not meet genome-wide significance, indicating potential false positives and the need for further validation.
Participant Demographics
Participants were from the Framingham Heart Study, including both men and women.
Statistical Information
P-Value
p < 10-5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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