Kidney Size and Function in Children with Vesicoureteral Reflux
Author Information
Author(s): Yan Hualin, Wu Cong, Zhou Jiehong, Huang Cairong, Ma Xue, Huang Yidong, Huang Lugang, Liu Juxian
Primary Institution: West China Hospital, Sichuan University, Chengdu, China
Hypothesis
This study aimed to explore the relationship between different VUR grades and IRR on ceVUS, and assess the impact of VUR and IRR on kidney size and function.
Conclusion
The study found that high-grade VUR and intrarenal reflux are associated with reduced kidney size and renal function in children.
Supporting Evidence
- 134 out of 220 uretero-renal units were diagnosed with VUR.
- 25 patients exhibited intrarenal reflux, exclusively in grade II VUR or higher.
- Patients with high-grade VUR and IRR had reduced kidney size compared to those without VUR or IRR.
- High-grade VUR was associated with more DMSA scars compared to those without VUR or IRR.
Takeaway
Kids with severe bladder problems can have smaller kidneys and worse kidney function, which can be seen with a special ultrasound test.
Methodology
The study reviewed ceVUS studies from January 2019 to December 2023, including 220 uretero-renal units from 110 children.
Limitations
Only 20 patients underwent DMSA scan, and the study did not compare with VCUG.
Participant Demographics
110 children (67 males and 43 females) with a median age of 32.6 months.
Statistical Information
P-Value
P<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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