Haplotype-sharing Analysis for Alcohol Dependence
Author Information
Author(s): Kleensang Andre, Franke Daniel, König Inke R, Ziegler Andreas
Primary Institution: Institute of Medical Biometry and Statistics, University Hospital Schleswig-Holstein, Campus Lübeck, University at Lübeck
Hypothesis
Can a novel linkage-based haplotype-sharing approach using Mantel statistics identify genetic regions associated with alcohol dependence?
Conclusion
The study identified four significant regions on chromosomes 4, 8, 16, and 20 associated with alcohol dependence.
Supporting Evidence
- Four regions on chromosomes 4, 8, 16, and 20 showed significant p-values.
- The lowest p-value was found at marker tsc0520638 on chromosome 16.
- Three of the four regions had been reported in previous studies.
Takeaway
Researchers looked at family data to find parts of DNA linked to alcohol dependence, and they found some important areas on different chromosomes.
Methodology
The study used a haplotype-sharing Mantel statistic applied to autosomal data from a genome-wide scan.
Limitations
The permutation approach may destroy heritability, which needs further investigation.
Participant Demographics
143 families with 1,380 study samples, affected individuals met DSM-III-R criteria for alcohol dependence.
Statistical Information
P-Value
< 0.0001
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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