Malaria Exposure in Antananarivo, Madagascar
Author Information
Author(s): Domarle Olivier, Razakandrainibe Romy, Rakotomalala Emma, Jolivet Laurence, Randremanana Rindra Vatosoa, Rakotomanana Fanjasoa, Ramarokoto Charles Emile, Soares Jean-Louis, Ariey Frédéric
Primary Institution: Institut Pasteur de Madagascar
Hypothesis
What is the seroprevalence of malaria in the urban population of Antananarivo?
Conclusion
Malaria transmission levels are low in Antananarivo, but seroprevalence is high, primarily due to travel outside the city.
Supporting Evidence
- The seroprevalence of IgG+IgA+IgM was found to be 56.1%.
- Travel outside Antananarivo was identified as a major risk factor for malaria exposure.
- The study used a representative sample of 1,059 healthy volunteers.
Takeaway
This study found that many people in Antananarivo have been exposed to malaria, mostly when they travel outside the city, even though malaria is not commonly transmitted within the city itself.
Methodology
Serological studies were conducted using an indirect fluorescent antibody test (IFAT) on serum samples from a representative population.
Potential Biases
Logistics of sample collection may have led to an underrepresentation of men who were at work during the study.
Limitations
The study's male/female sex ratio was skewed, potentially affecting the results.
Participant Demographics
The mean age of participants was 29.56 years, with a male/female ratio of 0.59; most had settled in Antananarivo in the last four years.
Statistical Information
P-Value
0.021
Confidence Interval
[1.005 1.019]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website