Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective
2011
Branched-Chain Amino Acids and Aging
publication
Evidence: moderate
Author Information
Author(s): Valerio Alessandra, D'Antona Giuseppe, Nisoli Enzo
Hypothesis
Dietary BCAA supplementation might be a health-promoting strategy in aged patients at risk.
Conclusion
BCAA supplementation improves motor coordination and endurance and promotes longevity in male mice.
Supporting Evidence
- BCAA supplementation has been shown to support mitochondrial biogenesis in middle-aged mice.
- Long-term dietary supplementation with BCAAs increased average lifespan in male mice.
- BCAAs may help improve physical endurance and motor coordination in older individuals.
Takeaway
Eating certain amino acids can help older people stay healthy and live longer.
Methodology
The study reviews existing knowledge from various model organisms and human studies on the effects of BCAAs on aging.
Limitations
The effects of BCAA supplementation were not tested in all age groups and specific mechanisms remain unclear.
Want to read the original?
Access the complete publication on the publisher's website