New Markers for Prostate Cancer Prognosis
Author Information
Author(s): Knight J F, Shepherd C J, Rizzo S, Brewer D, Jhavar S, Dodson A R, Cooper C S, Eeles R, Falconer A, Kovacs G, Garrett M D, Norman A R, Shipley J, Hudson D L
Primary Institution: The Institute of Cancer Research
Hypothesis
Basal cell features are key in the development of prostate tumors.
Conclusion
TEAD1 and c-Cbl are novel basal cell markers that correlate with poor clinical outcomes in prostate cancer.
Supporting Evidence
- Increased protein levels of TEAD1 and c-Cbl were associated with decreased patient survival.
- Knockdown of TEAD1 or c-Cbl reduced proliferation in prostate cancer cell lines.
- TEAD1 and c-Cbl were confirmed as novel basal cell markers through immunofluorescence.
Takeaway
Researchers found two new markers in prostate cancer that can help predict how serious the disease might be.
Methodology
RNA from basal and luminal cells isolated from benign tissue was subjected to expression profiling and analyzed using tissue microarrays.
Limitations
PSA values were unavailable for many patients due to the long follow-up period.
Participant Demographics
Patients undergoing transurethral resection of the prostate for BPH, median age 64 years.
Statistical Information
P-Value
0.0009
Confidence Interval
95% CI 1.02–2.37
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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