GRIM-19 and its role in reducing fibrosis in systemic sclerosis
Author Information
Author(s): Jeong Ha Yeon, Park Jin-Sil, Choi Jeong Won, Lee Kun Hee, Yang Seung Cheon, Kang Hye Yeon, Cho Sang Hee, Lee Seon-Yeong, Lee A Ram, Park Youngjae, Park Sung-Hwan, Cho Mi-La
Primary Institution: Catholic University of Korea
Hypothesis
The study investigates the role of GRIM-19 in the development of systemic sclerosis (SSc) and its interaction with STAT3.
Conclusion
GRIM-19 helps control fibrosis in systemic sclerosis by interacting with mitochondrial STAT3.
Supporting Evidence
- Overexpression of GRIM-19 reduced dermal thickness and fibrosis in SSc mice.
- GRIM-19 overexpression decreased the frequency of Th2 and Th17 cells in SSc mice.
- Mitophagic dysfunction promoted fibrosis in mice lacking PINK1.
Takeaway
Researchers found that a protein called GRIM-19 can help reduce skin thickening and inflammation in mice with a disease that causes fibrosis.
Methodology
The study used a murine model of systemic sclerosis induced by bleomycin and assessed the effects of GRIM-19 overexpression on fibrosis and immune cell infiltration.
Participant Demographics
Eight-week-old male C57BL/6 mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website