Expression of the novel tumour suppressor p33ING1 is independent of p53
2000
Study on Tumor Suppressor p33ING1 and Its Independence from p53
publication
Author Information
Author(s): Cheung K-J J Jr, Bush J A, Jia W, Li G
Primary Institution: University of British Columbia and Vancouver Hospital and Sciences Centre
Hypothesis
Is the expression of ING1 dependent on p53?
Conclusion
The expression of ING1 is independent of p53 status.
Supporting Evidence
- ING1 mRNA and protein levels were similar in p53+/+ and p53–/– murine organs.
- UVB irradiation increased ING1 expression in normal human epithelial keratinocytes and HaCaT cells.
- UVB did not induce ING1 expression in dermal fibroblasts from both p53+/+ and p53–/– mice.
Takeaway
This study found that a protein called ING1 can work without needing another protein called p53, which is important for stopping cancer.
Methodology
The study used a p53-knockout mouse model and human keratinocyte cell lines to assess ING1 expression levels.
Digital Object Identifier (DOI)
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