Aneuploidy and Prognosis in Lung Cancer
Author Information
Author(s): Choma D, Daurès J-P, Quantin X, Pujol J L
Primary Institution: Centre Hospitalier Universitaire de Montpellier
Hypothesis
What is the prognostic effect of aneuploidy in surgically resected non-small-cell lung cancer?
Conclusion
Patients with aneuploid non-small-cell lung cancer have a higher risk of death compared to those with nearly diploid tumors.
Supporting Evidence
- Patients with nearly diploid tumors had a significant reduction in risk of death at 1, 2, 3, and 4 years.
- The odds ratios for reduction in risk of death were 0.51, 0.51, 0.45, and 0.67 for 1 to 4 years respectively.
- At 5 years, the reduction in risk of death was less significant with an odds ratio of 0.87.
Takeaway
This study found that having a certain type of lung cancer with abnormal DNA makes it more likely for patients to die sooner after surgery.
Methodology
A meta-analysis of 35 trials assessing the prognostic effect of aneuploidy in non-small-cell lung cancer.
Limitations
The study could not explain the significant statistical heterogeneity observed.
Participant Demographics
2626 patients with non-small-cell lung cancer and aneuploid DNA content.
Statistical Information
P-Value
p<10−4
Confidence Interval
(0.64–0.67)
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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