Sleep quality and the cortisol and alpha-amylase awakening responses in adolescents with depressive disorders
2024

Sleep Quality and Stress Responses in Depressed Adolescents

Sample size: 64 publication 10 minutes Evidence: moderate

Author Information

Author(s): Krempel Rebekka, Jarvers Irina, Ecker Angelika, Schleicher Daniel, Brunner Romuald, Kandsperger Stephanie

Primary Institution: University of Regensburg, Germany

Hypothesis

Adolescents with depressive disorders will have lower objective and subjective sleep quality than healthy controls.

Conclusion

Adolescents with depressive disorders experience significantly worse subjective sleep quality and prolonged sleep onset latency compared to healthy controls, but no significant differences in cortisol or alpha-amylase levels were found.

Supporting Evidence

  • Participants with depressive disorders reported significantly lower subjective sleep quality scores compared to healthy controls.
  • Prolonged sleep onset latency was observed in adolescents with depression.
  • Correlations were found between subjective sleep quality and objective sleep measures.

Takeaway

Teens with depression often have trouble sleeping well, which can make their depression worse. Helping them sleep better might help them feel better overall.

Methodology

The study compared subjective and objective sleep quality between 35 adolescents with depressive disorders and 29 healthy controls over 7 days, using questionnaires and actigraphy, along with saliva samples for cortisol and alpha-amylase analysis.

Potential Biases

Potential bias due to self-reported measures and the exclusion of participants with comorbidities other than anxiety disorders.

Limitations

The study's sample size was limited, and the groups differed in sex distribution, pubertal status, and educational attainment, which may affect the generalizability of the findings.

Participant Demographics

35 adolescents with depressive disorders (80% female) and 29 healthy controls (65.5% female), age-matched.

Statistical Information

P-Value

P < 0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1192/bjo.2024.730

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