Perfluorinated Compounds and Central Precocious Puberty in Girls During COVID-19
Author Information
Author(s): Li Haidan, Xie Manfang, Luo Hailing, Cai Yuhua, Liu Li, Li Hongai, Hai Yuanping, Ren Yi, Xue Jing, He Xiaojie, Huang Xiaoyan, Xiang Wei
Primary Institution: Hainan Medical University School of Pediatrics
Hypothesis
This study aimed to explore the impact of perfluorinated endocrine disruptors on central precocious puberty in girls.
Conclusion
Perfluorinated compounds may promote central precocious puberty in girls by interfering with various biological pathways.
Supporting Evidence
- Principal component analysis revealed distinct metabolic profiles between the CPP and control groups.
- A total of 511 metabolites were identified, with 296 up-regulated and 255 down-regulated in the CPP group.
- Three perfluorinated compounds were significantly upregulated in the CPP group.
- KEGG pathway enrichment analysis suggested multiple pathways involved in the CPP process regulated by these compounds.
Takeaway
This study found that certain chemicals in our environment might be making girls start puberty too early, especially during the COVID-19 pandemic.
Methodology
Serum samples from 100 girls with central precocious puberty and 100 healthy controls were analyzed using untargeted metabolomics profiling.
Limitations
The study did not perform qualitative or quantitative detection of metabolites and pathways, which requires further research.
Participant Demographics
100 girls with central precocious puberty and 100 healthy controls, all from Hainan Province, China.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website