Pathology Characteristics and Breast Cancer Screening Outcomes
Author Information
Author(s): Anderson T J, Alexander F E, Lamb J, Smith A, Forrest A P M
Primary Institution: University of Edinburgh
Hypothesis
Pathology characteristics can predict outcomes in breast cancer screening trials.
Conclusion
Pathology characteristics significantly predict survival outcomes in breast cancer patients, particularly in operable cases.
Supporting Evidence
- 55.7% of the cancers were in the screening arm, which had more operable cases.
- The reduction in inoperable breast cancers was a notable effect of the trial.
- In operable invasive cases, various pathology features showed significant association with survival.
Takeaway
Doctors can use certain features of breast cancer to better predict how well patients will do after treatment.
Methodology
The study analyzed 1029 cancers from the Edinburgh Randomized Trial of breast screening over 14 years.
Limitations
The weighting factors for pathology indicators in the Nottingham Prognostic Index may not be optimal for the trial population.
Participant Demographics
The majority of participants were women invited to mammographic screening in the UK.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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