First-pass perfusion CMR predicts heart function after infarction in rats
Author Information
Author(s): Stuckey Daniel J, Carr Carolyn A, Meader Stephanie J, Tyler Damian J, Cole Mark A, Clarke Kieran
Primary Institution: Department of Physiology, Anatomy and Genetics, University of Oxford
Hypothesis
First-pass CMR can be used as an early indicator of infarct severity in rat hearts.
Conclusion
First-pass CMR provides a predictive measure of the severity of myocardial impairment caused by infarction in a rodent model of heart failure.
Supporting Evidence
- First-pass CMR at 2 and 8 days following infarction better predicted outcome than traditional measures like ejection fraction.
- Perfusion delay was significantly longer in infarcted regions compared to remote regions.
- Significant correlations were found between perfusion delay and later measures of heart function.
Takeaway
This study shows that a special heart imaging technique can help doctors understand how badly a rat's heart is hurt after a heart attack.
Methodology
The study used first-pass CMR imaging to assess myocardial perfusion in isolated and in vivo rat hearts after inducing myocardial infarction.
Limitations
The study's findings may not directly translate to human patients due to differences in heart size and function.
Participant Demographics
Female Wistar rats were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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