Case of Herpes Simplex Virus Infection in a Woman with Rheumatoid Arthritis
Author Information
Author(s): Justice Elizabeth Ann, Khan Sophia Yasmin, Logan Sarah, Jobanputra Paresh
Primary Institution: Rheumatology Department, Selly Oak Hospital, University Hospital Birmingham NHS Trust
Conclusion
This case highlights the potential for disseminated herpes simplex virus infection following treatment with infliximab in immunosuppressed patients.
Supporting Evidence
- This is the first reported case of widespread cutaneous HSV-1 infection following treatment with infliximab.
- The patient developed pustular psoriasis while on etanercept, which worsened upon re-challenge.
- Acyclovir was effective in resolving the herpes simplex lesions.
Takeaway
A woman with rheumatoid arthritis got a serious skin infection after taking a medicine called infliximab, but she got better after treatment with another medicine.
Methodology
The case was presented with clinical observations and laboratory tests including polymerase chain reaction for HSV-1.
Limitations
The study is based on a single case report, limiting generalizability.
Participant Demographics
A 49-year-old woman with seronegative rheumatoid arthritis.
Digital Object Identifier (DOI)
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