CCL2 Gene Polymorphism and Its Role in Tuberculosis in Chinese Children
Author Information
Author(s): Feng Wei-Xing, Mokrousov Igor, Wang Bin-Bin, Nelson Hugh, Jiao Wei-Wei, Wang Jing, Sun Lin, Zhou Si-Rui, Xiao Jing, Gu Yi, Wu Xi-Rong, Ma Xu, Shen Adong
Primary Institution: Beijing Pediatric Research Institute, Beijing Children's Hospital affiliated to Capital Medical University, Beijing, China
Hypothesis
Does the CCL2 gene polymorphism rs4586 influence the susceptibility to tuberculosis in Han Chinese pediatric patients?
Conclusion
The study found that the CCL2 tag SNP rs4586-C allele is associated with pediatric tuberculosis disease in males, indicating that gender may affect susceptibility to TB even in children.
Supporting Evidence
- The C allele was found at a higher rate in the male TB subgroup (P=0.045).
- The TT genotype was significantly associated with lower CSF mononuclear leukocyte counts in TBM patients (P=0.001).
- The study included 301 TB cases and 338 controls, all of whom were BCG vaccinated.
Takeaway
This study looked at a gene that helps the body fight infections and found that a specific version of this gene might make boys more likely to get tuberculosis.
Methodology
The study analyzed the distribution of the CCL2 gene polymorphism in 301 TB cases and 338 non-infected controls, all BCG vaccinated.
Potential Biases
Potential bias due to the selection of controls and the challenges in diagnosing TB in BCG-vaccinated children.
Limitations
The study had a small sample size for some subgroups and lacked detailed demographic information for comparison.
Participant Demographics
All participants were Han Chinese children, with a mean age of approximately 5.9 years in the TB group.
Statistical Information
P-Value
0.029
Confidence Interval
95% CI 1.01–1.79
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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