Neural Tube Defects in Newborns in Ethiopia
Author Information
Author(s): Gebremariam Beminet Moges, Hailu Dejene, Stoecker Barbara J., Mulugeta Afework
Primary Institution: School of Public Health, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia
Hypothesis
What is the pooled prevalence and determinants of neural tube defects among newborns in Ethiopia?
Conclusion
The pooled birth prevalence of neural tube defects in Ethiopia was found to be high, indicating a need for effective prevention interventions.
Supporting Evidence
- The pooled birth prevalence of neural tube defects was 83.40 per 10,000 births.
- Women’s intake of folic acid supplements was identified as a protective factor for NTDs.
- Stillbirth history and exposure to drugs during pregnancy were significant risk factors for NTDs.
- Radiation and pesticide exposure during pregnancy were also linked to higher rates of NTDs.
Takeaway
This study found that many babies in Ethiopia are born with serious brain and spine problems called neural tube defects, but taking vitamins before and during pregnancy can help prevent them.
Methodology
A systematic review and meta-analysis were conducted using data from various databases and studies on neural tube defects in Ethiopia.
Potential Biases
There was significant evidence of publication bias identified in the analysis.
Limitations
Most studies were conducted in health facilities, which may underestimate the prevalence due to unreported stillbirths and miscarriages from home deliveries.
Participant Demographics
The study included newborns and children aged 0–17 years from various regions in Ethiopia.
Statistical Information
P-Value
0.0178
Confidence Interval
95% CI: 60.78, 106.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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