Immune Response and Coagulopathy in Blunt Thoracic Trauma
Author Information
Author(s): Băetu Alexandru Emil, Mirea Liliana Elena, Cobilinschi Cristian, Grințescu Ioana Cristina, Grințescu Ioana Marina, Kondili Eumorfia, Giuggioli Dilia, Yamamoto Norio
Primary Institution: Carol Davila University of Medicine and Pharmacy
Hypothesis
Blunt thoracic trauma patients exhibit distinct patterns of coagulation and inflammation abnormalities identifiable by the use of readily available hemogram-derived markers.
Conclusion
Blunt thoracic trauma patients exhibit distinct phenotypes of the immune response and coagulopathy from the early stages, with moderate inflammation potentially offering a survival benefit.
Supporting Evidence
- A U-shaped distribution of mortality was found, with high rates of early deaths in patients with an NLPR value of <3.1 and high rates of late deaths in patients with NLPR > 9.5.
- Patients expressing moderate inflammation and inflammation-induced hypercoagulation (NLPR between 3.1 and 9.5) may have a survival benefit.
- The NLPR cut-off for predicting early deaths and the need for massive transfusion was 3.1.
Takeaway
This study looks at how patients with chest injuries respond to trauma and how certain blood tests can help predict their chances of survival.
Methodology
A retrospective observational analysis of 86 patients with blunt thoracic trauma from a single trauma center.
Potential Biases
Selection bias due to the single-center design and exclusion criteria.
Limitations
The study included a relatively small number of patients from a single trauma center, and selection bias could not be avoided.
Participant Demographics
Mean age of 44.36 years, majority were men.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website