Glutathione S-transferase Levels in Breast Cancer
Author Information
Author(s): A.F. Howie, W.R. Miller, R.A. Hawkins, A.R. Hutchinson, G.J. Beckett
Primary Institution: University Departments of Clinical Chemistry and Surgery, The Royal Infirmary, Edinburgh, UK
Hypothesis
Is there a relationship between glutathione S-transferase expression and estrogen receptor status in breast tumors?
Conclusion
Higher levels of glutathione S-transferase Pi, B1, and B2 were found in estrogen receptor-poor breast tumors compared to estrogen receptor-rich tumors.
Supporting Evidence
- GST Pi was expressed most strongly in all cytosols.
- GST Mu was found in only 28 of the 58 breast tumor cytosols.
- The concentrations of GST Pi were significantly higher in ER-poor tumor cytosols than in ER-rich tumors.
Takeaway
This study looked at proteins in breast cancer and found that certain proteins are more common in tumors that don't have estrogen receptors.
Methodology
The study measured glutathione S-transferase levels in tumor cytosols using radioimmunoassays.
Limitations
The study did not find associations between GST expression and age, menopausal status, lymph node involvement, or tumor T stage.
Participant Demographics
Fifty-eight women with histologically proven invasive breast cancer.
Statistical Information
P-Value
p<0.01, p<0.001
Statistical Significance
p<0.01
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