Dorema kopetdaghense: A Potent Antifungal Plant
Author Information
Author(s): Shakeri Abolfazl, Mashhadi Esmaeilabadi Aliakbar, Soheili Vahid, Mottaghipisheh Javad, Emami Seyed Ahmad, Akhtari Javad, Tayarani-Najaran Zahra
Primary Institution: Mashhad University of Medical Sciences
Hypothesis
The study aimed to assess the antifungal, antibacterial, antioxidant, and cytotoxic activities of root extracts of Dorema kopetdaghense.
Conclusion
The study found that Dorema kopetdaghense has strong antifungal and antioxidant activities without notable cytotoxicity.
Supporting Evidence
- The extracts showed remarkable antifungal effects against Candida albicans with MIC and MBC values of 10 µg/mL.
- No cytotoxicity was observed in the case of selected cancer cells.
- The methanolic extract exhibited the highest free radicals inhibition with an IC50 value of 20.11 µg/mL.
Takeaway
Dorema kopetdaghense is a plant that can help fight fungi and has good antioxidant properties, making it safe to use.
Methodology
The study used methanolic crude extract and its sub-fractions to test antifungal, antibacterial, antioxidant, and cytotoxic activities.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website