Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets
Author Information
Author(s): Sørensen Thorkild I. A, Boutin Philippe, Taylor Moira A, Larsen Lesli H, Verdich Camilla, Petersen Liselotte, Holst Claus, Echwald Søren M, Dina Christian, Toubro Søren, Petersen Martin, Polak Jan, Clément Karine, Martínez J. Alfredo, Langin Dominique, Oppert Jean-Michel, Stich Vladimir, Macdonald Ian, Arner Peter, Saris Wim H. M, Pedersen Oluf, Astrup Arne, Froguel Philippe
Primary Institution: Institute of Preventive Medicine, Danish Epidemiology Science Centre, Copenhagen University Hospital, Copenhagen, Denmark
Hypothesis
Do genetic polymorphisms associated with obesity influence weight loss in obese individuals on different dietary interventions?
Conclusion
Polymorphisms in obesity-related candidate genes have a minor role in modulating weight changes induced by low-fat or high-fat diets.
Supporting Evidence
- 771 participants were recruited for the trial.
- Participants were assigned to either a low-fat or high-fat diet.
- Weight loss was measured over a 10-week period.
- Genetic analysis was performed on 642 participants who completed the intervention.
- None of the genetic variants studied showed a significant association with weight loss.
Takeaway
This study looked at whether certain genes affect how much weight people lose on different diets. It found that these genes don't really change how much weight people lose.
Methodology
Randomised, parallel, two-arm, open-label multi-centre trial with dietary interventions over 10 weeks.
Potential Biases
Potential population stratification and selection bias due to strict inclusion criteria.
Limitations
The study involved multiple comparisons which may lead to chance findings, and the sample size may not be sufficient for detecting significant effects.
Participant Demographics
771 obese adults, predominantly Caucasian, aged 20-50 years.
Digital Object Identifier (DOI)
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