VEGF's Role in Cervical Remodeling in Pregnant Rodents
Author Information
Author(s): Mowa Chishimba, Li Tianbo, Jesmin Subrina, Folkesson Hans G, Usip Sharon E, Papka Raymond E, Hou Guichuan
Primary Institution: Appalachian State University
Hypothesis
Factors that regulate the cervical vasculature, particularly VEGF, play a critical role in cervical remodeling.
Conclusion
VEGF regulates key factors involved in cervical remodeling and induces cervical epithelial growth.
Supporting Evidence
- About 4,200 genes were altered in expression by VEGF.
- VEGF elevated VCAM-1 levels by about 10 folds.
- VEGF agents altered mRNA levels of decorin, eNO, PLC, and PKC.
Takeaway
VEGF helps the cervix change during pregnancy, which is important for childbirth.
Methodology
DNA microarray analysis, Real-time PCR, and SEM were used to analyze gene expression and cervical morphology.
Limitations
The study only shows alterations in mRNA levels and not protein.
Participant Demographics
Timed-pregnant Sprague Dawley rats and pregnant mice.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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