Regulatory Network of Transcription Factors in Mouse Brain
Author Information
Author(s): Li Jing, Liu Zijing J, Pan Yuchun C, Liu Qi, Fu Xing, Cooper Nigel G, Li Yixue, Qiu Mengsheng, Shi Tieliu
Primary Institution: Shanghai Jiao Tong University
Hypothesis
What are the regulatory mechanisms of bHLH transcription factors in the mouse brain?
Conclusion
The constructed regulatory network provides a reliable framework for understanding the role of bHLH transcription factors in mouse brain development and function.
Supporting Evidence
- The network includes 15 bHLH transcription factors and 153 target genes.
- Over 70% of TF-target gene pairs were validated by the presence of TF binding sites.
- Literature mining provided additional support for five modules.
Takeaway
Scientists created a map showing how certain proteins in the mouse brain work together to control gene activity, which helps us understand brain development.
Methodology
The regulatory network was constructed using genome-wide gene expression profiles and the module networks method.
Limitations
The study focused only on bHLH transcription factors and their target genes, which may not represent the entire regulatory network in the mouse brain.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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