XAF1 Expression and Clear-Cell Renal Cancer Progression
Author Information
Author(s): Kempkensteffen Carsten, Fritzsche Florian Rudolf, Johannsen Manfred, Weikert Steffen, Hinz Stefan, Dietel Manfred, Riener Marc-Oliver, Moch Holger, Jung Klaus, Krause Hans, Miller Kurt, Kristiansen Glen
Primary Institution: Charité – Universitätsmedizin Berlin
Hypothesis
The study investigates the role of XAF1 protein expression in the progression of clear-cell renal cell carcinoma (ccRCC).
Conclusion
Low XAF1 protein levels in ccRCCs are associated with poor tumor differentiation, advanced tumor stages, and unfavorable outcomes.
Supporting Evidence
- Low XAF1 expression was associated with progression of tumor stage and grade.
- Patients with low XAF1 levels had significantly shortened overall survival times.
- XAF1 expression did not provide independent prognostic information in multivariable analyses.
Takeaway
This study found that when a protein called XAF1 is low in kidney cancer cells, the cancer tends to grow worse and patients may not live as long.
Methodology
The study assessed XAF1 protein expression in tumor tissue from 291 ccRCC patients and 68 normal renal tissue samples using immunohistochemistry.
Limitations
XAF1 did not provide independent prognostic information when adjusting for standard pathological parameters.
Participant Demographics
197 men and 94 women diagnosed with ccRCC.
Statistical Information
P-Value
p = 0.040 for tumor stage, p < 0.001 for grade, p = 0.018 for overall survival.
Confidence Interval
95%: 80 – 101 for high XAF1 expression, 68 – 89 for low XAF1 expression.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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