Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer
1999
Targeting Small-Cell Lung Cancer with Vasopressin Promoter
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Coulson J M, Stanley J, Woll P J
Primary Institution: University of Nottingham
Hypothesis
Can the vasopressin promoter be used for SCLC-specific targeting?
Conclusion
A short region of the vasopressin promoter can drive strong expression in small-cell lung cancer cells.
Supporting Evidence
- Arginine vasopressin is found in up to two-thirds of small-cell lung cancer tumors.
- Promoter fragments directed reporter gene expression specifically in SCLC cell lines.
- The 199-bp fragment contained elements necessary for strong SCLC-specific promoter activity.
Takeaway
Researchers found a part of a gene that can help target treatments specifically to a type of lung cancer called small-cell lung cancer.
Methodology
Human vasopressin promoter fragments were cloned and tested in various cell lines.
Digital Object Identifier (DOI)
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