Choline-stabilized orthosilicic acid and bone health in osteopenic women
Author Information
Author(s): Tim D Spector, Mario R Calomme, Simon H Anderson, Gail Clement, Liisa Bevan, Nathalie Demeester, Rami Swaminathan, Ravin Jugdaohsingh, Dirk A Vanden Berghe, Jonathan J Powell
Primary Institution: St Thomas' Hospital, Kings College, London, UK
Hypothesis
Does choline-stabilized orthosilicic acid (ch-OSA) supplementation improve bone formation markers in osteopenic women when combined with calcium and vitamin D3?
Conclusion
Choline-stabilized orthosilicic acid combined with calcium and vitamin D3 may improve bone collagen metabolism in osteopenic women.
Supporting Evidence
- Ch-OSA supplementation showed a significant increase in the bone formation marker PINP at 12 months.
- Subgroup analysis indicated significant changes in femoral neck BMD for the 6 mg dose compared to placebo.
- No adverse events related to ch-OSA were reported during the study.
- Biochemical safety parameters remained within normal ranges throughout the study.
- Compliance rates were high across all treatment groups.
Takeaway
This study tested a supplement called ch-OSA to see if it helps bones in women with low bone density. It looks like it might help make bones stronger when taken with calcium and vitamin D.
Methodology
A double-blind placebo-controlled trial over 12 months with 184 osteopenic women, measuring bone formation markers and bone mineral density.
Potential Biases
Potential bias due to the high dropout rate and the small sample size in some treatment groups.
Limitations
The dropout rate was higher than expected, which may have affected the study's power.
Participant Demographics
Osteopenic, mostly post-menopausal Caucasian women, mean age 60.7 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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