SPRINT Protocol for Blood Sugar Control in ICU Patients
Author Information
Author(s): Chase J Geoffrey, Shaw Geoffrey, Le Compte Aaron, Lonergan Timothy, Willacy Michael, Wong Xing-Wei, Lin Jessica, Lotz Thomas, Lee Dominic, Hann Christopher
Primary Institution: University of Canterbury
Hypothesis
Does the SPRINT protocol improve glycaemic control and reduce mortality in critically ill patients compared to previous methods?
Conclusion
The SPRINT protocol achieved better glycaemic control and reduced mortality rates in critically ill patients compared to historical data.
Supporting Evidence
- 53.9% of blood glucose measurements were in the target range of 4.4 to 6.1 mmol/L.
- Hospital mortality was reduced from 34.1% to 25.4% for patients with an ICU length of stay of 3 days or more.
- The average blood glucose level on SPRINT was 6.0 mmol/L with a standard deviation of 1.5 mmol/L.
Takeaway
The SPRINT protocol helps keep blood sugar levels steady in very sick patients, which can make them healthier and help them live longer.
Methodology
The SPRINT protocol was implemented in an ICU, and its effects on glycaemic control and mortality were compared with a retrospective cohort.
Potential Biases
Potential biases due to the non-randomized nature of the cohort selection.
Limitations
The study relied on a retrospective cohort for comparison, which may not fully account for all variables.
Participant Demographics
Patients included in the study had a median APACHE II score of 18, indicating a severely ill population.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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