Novel anti-inflammatory role of SLPI in adipose tissue and its regulation by high fat diet
2011
The Role of SLPI in Reducing Inflammation in Fat Tissue
Sample size: 16
publication
Evidence: moderate
Author Information
Author(s): Adapala Venkata J, Buhman Kimberly K, Ajuwon Kolapo M
Primary Institution: Purdue University
Hypothesis
Obesity induces expression of SLPI in adipose tissue where it functions to counteract adipocyte inflammation.
Conclusion
SLPI is expressed in adipocytes and adipose tissue, potentially playing a key role in reducing inflammation.
Supporting Evidence
- SLPI expression is higher in visceral fat compared to subcutaneous fat.
- SLPI is mostly expressed in the stromal vascular fraction rather than in adipocytes.
- Activation of TLR2 and TLR4 leads to increased SLPI expression.
- SLPI reduces IL-6 expression in adipocytes treated with LPS.
Takeaway
When mice eat a lot of fat, a protein called SLPI helps calm down inflammation in their fat tissue.
Methodology
Male C57BL6 mice were fed high fat or control diets for 12 weeks, and SLPI expression was measured in adipose tissue using western blotting and PCR.
Participant Demographics
Male C57BL6 mice, 8 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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