Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
2003
Carbonic Anhydrases in Cancer
publication
Evidence: moderate
Author Information
Author(s): Potter C P S, Harris A L
Primary Institution: Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Hypothesis
The review aims to address the association of carbonic anhydrases with cancer biology.
Conclusion
Carbonic anhydrases may play significant roles in cancer biology and could serve as potential therapeutic targets.
Supporting Evidence
- Carbonic anhydrases are involved in maintaining pH levels in tumors.
- CAIX and CAXII are associated with tumor hypoxia and may serve as biomarkers.
- CA inhibitors have shown potential in reducing cancer cell growth in vitro.
Takeaway
Carbonic anhydrases are special proteins that help cancer cells survive in tough conditions, and scientists think they could be important for new cancer treatments.
Methodology
The review summarizes recent advances in the understanding of carbonic anhydrases in cancer biology.
Digital Object Identifier (DOI)
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