Tetracycline-Resistant Vibrio cholerae O1 in Kolkata, India
Author Information
Author(s): Bhattacharya Koel, Kanungo Suman, Sur Dipika, Sarkar Banwari Lal, Manna Byomkesh, Lopez Anna Lena, Bhattacharya Manjira, Nandy Suman, Niyogi Swapan Kumar
Primary Institution: National Institute of Cholera and Enteric Diseases, Kolkata, India
Hypothesis
The study aims to estimate the prevalence of cholera and identify potential risk factors in Kolkata, India.
Conclusion
The study found a significant increase in tetracycline resistance among Vibrio cholerae O1 isolates in Kolkata from 2004 to 2009.
Supporting Evidence
- 77% of the isolated V. cholerae O1 organisms were Ogawa serotype.
- Tetracycline resistance among isolates increased from 1% in 2004 to 76% in 2007.
- 99% of tetracycline-resistant strains were also resistant to furazolidone and trimethoprim/sulfamethoxazole.
- 43% of tetracycline-resistant isolates had high-level resistance (MIC >16 µg/mL).
- Resistance to tetracycline was <10% during 2004–2006.
Takeaway
In Kolkata, many bacteria that cause cholera are becoming resistant to tetracycline, a common medicine used to treat it.
Methodology
A community-based study was conducted with rectal swabs collected from patients with diarrhea to isolate and identify Vibrio cholerae.
Limitations
The reasons for the sudden rise in resistance in 2007 and its persistence are unclear.
Participant Demographics
The study was conducted in an impoverished urban area in Kolkata, India.
Digital Object Identifier (DOI)
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