Melanoma Cell Attachment, Invasion and Integrin Expression is Upregulated by the Proinflammatory Cytokine TNF- and Suppressed by the Anti-Inflammatory Peptide -MSH.
2002
Effects of Proinflammatory Cytokines on Melanoma Cell Behavior
publication
Evidence: moderate
Author Information
Author(s): E. Katerinaki, N. Zhu, J.W. Haycock, P. Eves, G.S. Evans, P.C. Lorigan, S. MacNeil
Primary Institution: University of Sheffield
Hypothesis
Do proinflammatory cytokines involved in wound healing promote melanoma invasion?
Conclusion
TNF- enhances melanoma cell attachment and invasion, while -MSH suppresses these effects.
Supporting Evidence
- TNF- increased cell attachment to various substrates.
- TNF- enhanced melanoma cell invasion through fibronectin.
- -MSH reduced cell attachment and invasion.
- Simultaneous exposure to -MSH and TNF- attenuated TNF-'s effects.
Takeaway
This study found that a substance called TNF- helps melanoma cells stick and invade more, while another substance, -MSH, makes it harder for them to do that.
Methodology
The study used a human melanoma cell line and examined the effects of TNF- and -MSH on cell attachment, invasion, and integrin expression.
Statistical Information
P-Value
0.042
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website