Comparing Hydroxyethyl Starch and Ringer Solution in Heart Surgery
Author Information
Author(s): Tiryakioğlu Osman, Yıldız Gürdeniz, Vural Hakan, Goncu Tugrul, Ozyazıcıoglu Ahmet, Yavuz Şenol
Primary Institution: Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey
Hypothesis
Does Hydroxyethyl starch (HES) 130-0.4 provide better outcomes than Ringer solution as a prime solution in cardiopulmonary bypass?
Conclusion
HES 130-0.4 solution is a viable alternative to Ringer solution for cardiopulmonary bypass without significant negative effects on coagulation or renal function.
Supporting Evidence
- INR levels were higher in the Ringer group, while blood urea and creatinine levels were higher in the HES group postoperatively.
- HES 130-0.4 did not increase the need for transfusion or drainage amount compared to Ringer solution.
- Platelet counts were statistically significantly higher in the HES group at 24 hours postoperatively.
Takeaway
This study looked at two types of fluids used during heart surgery. It found that one type, HES, works just as well as the standard one, Ringer solution, without causing problems.
Methodology
140 patients undergoing CABG were randomly assigned to receive either Ringer solution or HES 130-0.4 as a prime solution during cardiopulmonary bypass.
Limitations
The study excluded patients with preoperative renal insufficiency, which may limit the generalizability of the findings.
Participant Demographics
140 patients, no significant demographic differences between groups.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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