BOLD Imaging in Coronary Artery Disease
Author Information
Author(s): Luu Judy, Harker Jodi, Guensch Dominik, Hare James, Friedrich Matthias
Primary Institution: University of Calgary
Hypothesis
Can BOLD-sensitive CMR images detect and quantify alterations in myocardial oxygen levels in patients with CAD compared to fractional flow reserve?
Conclusion
BOLD-sensitive CMR may help identify significant coronary artery stenoses based on a reduced response to adenosine.
Supporting Evidence
- BOLD SI percent change was significantly less in patients with abnormal FFR values.
- Mean BOLD SI percent change was -4.62% for abnormal FFR and 8.54% for normal FFR.
- 73 segments were excluded from analysis, with 66% being apical.
Takeaway
This study shows that a special type of heart scan can help doctors find blockages in heart arteries by looking at how well blood is getting oxygen.
Methodology
Oxygen-sensitive BOLD CMR scans were performed on patients scheduled for coronary angiography, comparing BOLD signal changes during rest and hyperemia.
Limitations
Image quality, especially in apical segments, and suboptimal interobserver variability were significant limitations.
Participant Demographics
22 patients, average age 60 years, 19 males.
Statistical Information
P-Value
0.003
Confidence Interval
95% limits of agreement ranged from -23.6% to 27.8%
Statistical Significance
p=0.003
Digital Object Identifier (DOI)
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