Prognostic Factors in Ovarian Cancer
Author Information
Author(s): J.P.A. Baak, N.W. Schipper, E.C.M. Wisse-Brekelmans, Th. Ceelen, F.T. Bosman, H. van Geuns, J. Wils
Primary Institution: Free University Hospital and Comprehensive Cancer Center, Limburg, The Netherlands
Hypothesis
Do morphometric features and cellular DNA content provide prognostic value in advanced ovarian cancer patients treated with cis-platin?
Conclusion
Morphometric and flow cytometric analyses can significantly predict the prognosis of advanced ovarian cancer patients treated with cis-platin.
Supporting Evidence
- FIGO stage was the strongest single prognostic factor.
- Patients with a mean nuclear area >70 um2 were nearly all aneuploid.
- Only two combinations of features were associated with excellent prognosis.
Takeaway
Doctors can look at certain features of ovarian cancer cells to guess how well a patient might do after treatment.
Methodology
Patients were treated with cis-platin and their tumor features were analyzed for prognostic significance.
Limitations
The study was retrospective and only included invasive cancers, excluding borderline tumors.
Participant Demographics
Patients were aged 70 years or younger with stage III-IV epithelial ovarian carcinoma.
Statistical Information
P-Value
0.0002
Statistical Significance
p<0.00001
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