Tracing the Evolution of Protein Domains in Humans
Author Information
Author(s): Pal Lipika R, Guda Chittibabu
Primary Institution: Gen*NY*sis Center for Excellence in Cancer Genomics and Department of Epidemiology & Biostatistics, University at Albany, State University of New York
Hypothesis
What is the evolutionary origin of functional and conserved domains in the human proteome?
Conclusion
The study provides insights into the evolutionary origin and distribution of functional domains in the human proteome, highlighting the complexity and versatility of protein functions.
Supporting Evidence
- The study identified 88,025 domains in the human proteome.
- About 60% of human domains have origins at early evolutionary stages.
- The method used outperformed traditional methods in detecting functional domains.
Takeaway
This study looks at how different parts of proteins, called domains, have evolved in humans, helping us understand how our proteins work and why they are so complex.
Methodology
The study used a subtractive searching method to trace the origins of protein domains along the Homo sapiens lineage, employing the HHpred method for domain identification.
Limitations
The study is limited by the lack of assigned functional domains for about half of the residues in known proteins in eukaryotic species.
Digital Object Identifier (DOI)
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