Heparan sulphate inhibition of cell proliferation induced by TGF and PDGF
1993
Heparan Sulphate Inhibition of Cell Proliferation Induced by TGF and PDGF
publication
Evidence: moderate
Author Information
Author(s): Ian E. Silber, Jeanine M. Walenga, Jawed Fareed, Elizabeth J. Kovacs
Primary Institution: Loyola University
Hypothesis
Can glycosaminoglycans (GAGs) other than heparin prevent cell proliferation?
Conclusion
Heparan sulphate significantly inhibits the proliferation of smooth muscle cells and fibroblasts induced by growth factors.
Supporting Evidence
- Porcine heparan sulphate inhibited proliferation of smooth muscle cells by 88%.
- Beef mucosal heparins also blocked proliferation, but to a lesser extent.
- Continuous presence of heparan sulphate was not required for its inhibitory effects.
Takeaway
Heparan sulphate can stop certain cells from growing too much, which might help treat diseases where cells grow out of control.
Methodology
Cells were cultured with various glycosaminoglycans and their proliferation was measured using optical density after treatment with growth factors.
Limitations
The study does not explore the long-term effects of heparan sulphate on cell proliferation.
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