Network Analysis of Diseases Linked to Amyloid Deposition
Author Information
Author(s): Rizou Aikaterini E. I., Nasi Georgia I., Apostolakou Avgi E., Dimopoulos Meletios A., Kastritis Efstathios, Iconomidou Vassiliki A.
Primary Institution: National and Kapodistrian University of Athens
Hypothesis
Can a disease–protein–drug network reveal new insights into amyloidoses and potential drug repurposing?
Conclusion
The study identifies disease associations and drug candidates that may help treat diseases associated with amyloid deposition.
Supporting Evidence
- The network consists of 2347 nodes and 7114 edges, including 76 diseases and 1414 drugs.
- Commonalities between diseases were highlighted, suggesting potential drug repurposing.
- Polaprezinc was identified as a candidate for repurposing in amyotrophic lateral sclerosis and Parkinson's disease.
Takeaway
Researchers created a big map showing how different diseases and drugs are connected, which might help find new ways to treat diseases caused by misfolded proteins.
Methodology
A disease–protein–drug network was constructed using data from various sources, including disease associations, protein interactions, and drug interactions.
Limitations
The majority of amyloidogenic proteins are not well-studied, and their interactions remain to be uncovered.
Digital Object Identifier (DOI)
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