PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma
1999
Inhibitor Reduces Invasiveness of Oral Cancer
Sample size: 24
publication
Evidence: high
Author Information
Author(s): Simon C, Hicks M J, Nemechek A J, Mehta R, Jr B W O'Malley, Goepfert H, Flaitz C M, Boyd D
Primary Institution: The University of Texas MD Anderson Cancer Center
Hypothesis
Does PD 098059, an inhibitor of ERK1 activation, reduce the invasiveness of head and neck squamous cell carcinoma?
Conclusion
The study found that PD 098059 significantly reduced the invasiveness of oral cancer tumors in mice.
Supporting Evidence
- In control mice, tumors infiltrated the genioglossus muscle in 10 out of 12 cases.
- In PD 098059-treated mice, tumors did not extend beyond the mylohyoid or geniohyoid muscles in 9 out of 12 cases.
- Neurotropism was observed in 6 out of 12 control mice but was completely abolished in PD 098059-treated mice.
Takeaway
This study shows that a special medicine can help stop oral cancer from spreading in mice.
Methodology
Mice were injected with tumor cells and treated with PD 098059 to assess tumor spread.
Participant Demographics
Nude mice were used in the study.
Statistical Information
P-Value
< 0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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