Shrimp Allergen Extract Immunotherapy Reduces Food Allergy Symptoms in Mice
Author Information
Author(s): Marhaeny Honey Dzikri, Rohmah Lutfiatur, Pratama Yusuf Alif, Kasatu Salsabilla Madudari, Miatmoko Andang, Addimaysqi Rafi, van den Bogaart Geert, Ho Franz Y., Taher Muhammad, Khotib Junaidi
Primary Institution: Airlangga University, Surabaya, Indonesia
Hypothesis
Does shrimp allergen extract (SAE) induce immunological tolerance in a gastro-food allergy mouse model?
Conclusion
SAE immunotherapy effectively reduces allergy symptoms and promotes immune tolerance in a mouse model of shrimp allergy.
Supporting Evidence
- SAE immunotherapy reduced systemic allergy symptom scores in allergic mice.
- IL-4 levels decreased in serum after SAE treatment.
- Foxp3 mRNA expression increased, indicating enhanced Treg cell activity.
- Degranulated mast cells in the ileum were significantly reduced after treatment.
- SAE immunotherapy showed sustained effects over time.
Takeaway
This study shows that a shrimp extract can help mice with shrimp allergies feel better and not react so badly to shrimp anymore.
Methodology
Mice were sensitized with shrimp allergen extract and treated with varying doses of SAE to evaluate the immunotherapy's effectiveness.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Female BALB/c mice aged 6-8 weeks.
Statistical Information
P-Value
p≤0.0001
Statistical Significance
p≤0.0001
Digital Object Identifier (DOI)
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