Streptococcus gallolyticus and Colorectal Cancer
Author Information
Author(s): David Michael Warner, Arunab Harish Mehta
Primary Institution: University of Cincinnati College of Medicine
Hypothesis
What are the mechanisms underlying the association between Streptococcus gallolyticus infection and colorectal cancer?
Conclusion
Streptococcus gallolyticus has mechanisms that promote its survival in the colorectal environment and contribute to the progression of colorectal cancer.
Supporting Evidence
- Sgg is associated with infective endocarditis and colorectal cancer.
- 65% of patients with Sgg-related endocarditis have colorectal adenomas or carcinomas.
- Sgg can adhere to and invade colonic epithelium, promoting cancer development.
Takeaway
There's a type of bacteria called Streptococcus gallolyticus that can make people sick and is linked to colon cancer. It has special features that help it grow in the gut and can even help cancer grow.
Methodology
The PubMed database was searched for articles on the role of Sgg in CRC formation, focusing on articles from the last 25 years that elucidated mechanisms of the association.
Limitations
The review is based on existing literature and may not cover all relevant studies or mechanisms.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website