Impact of Ovarian Cancer on Immune System Function
Author Information
Author(s): Taylor D D, Bender D P, Gerçel-Taylor Ç, Stanson J, Whiteside T L
Primary Institution: University of Louisville School of Medicine
Hypothesis
Can factors derived from ovarian cancer patients suppress the expression of the T-cell receptor zeta chain?
Conclusion
Sera and ascitic fluids from women with advanced ovarian cancer suppress the expression of the T-cell receptor zeta chain in a dose-dependent manner.
Supporting Evidence
- Decreased expression of the T-cell receptor zeta chain correlates with deficient immune responsiveness in ovarian cancer.
- The suppression of zeta chain expression was not observed with fluids from healthy women.
Takeaway
Women with ovarian cancer have substances in their blood that can weaken their immune system by reducing a key part of their immune cells.
Methodology
Sera and ascitic fluids from women with advanced ovarian cancer were analyzed for their effect on TcR zeta chain expression.
Participant Demographics
Women with advanced ovarian cancer and healthy women.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website