Childbearing and Oesophageal Adenocarcinoma
Author Information
Author(s): Lagergren J, Jansson C
Primary Institution: Karolinska Institutet, Stockholm, Sweden
Hypothesis
Women are effectively protected against development of oesophageal and cardia adenocarcinoma through their normal levels of oestrogens.
Conclusion
The study found no evidence that childbearing reduces the risk of oesophageal or cardia adenocarcinoma.
Supporting Evidence
- Childless women were not at increased risk compared to childbearing women.
- Women with 0–1 children were not at higher risk than those with at least three children.
- The study included a thorough documentation of tumours and high participation rates.
Takeaway
The study looked at whether having children affects the risk of a type of cancer in the esophagus, and it found that not having children does not increase that risk.
Methodology
A population-based case-control study involving 63 women with oesophageal or cardia adenocarcinoma and 141 controls, with data collected through interviews.
Potential Biases
Potential confounding factors were adjusted for, but the rarity of the disease among women limits the findings.
Limitations
The sample size was too limited to rule out moderate associations.
Participant Demographics
Female Swedish residents under 80 years old.
Statistical Information
P-Value
0.82
Confidence Interval
95% CI=0.25–2.73
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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