Breast Cancer Prognosis Using Invasion and Proliferation Markers
Author Information
Author(s): Harbeck N, Dettmar P, Thomssen C, Berger U, Ulm K, Kates R, Höfler H, Jänicke F, Graeff H, Schmitt M
Primary Institution: Technische Universität München
Hypothesis
Can invasion and proliferation markers improve risk-group discrimination in node-negative breast cancer?
Conclusion
PAI-1 is a strong and independent prognostic factor in node-negative breast cancer after a 6-year follow-up.
Supporting Evidence
- PAI-1 was significant for disease-free survival with a p-value of less than 0.001.
- The combination of PAI-1 and uPA provided the best risk group discrimination.
- PAI-1 was the only independently significant factor in Cox analysis for overall survival.
Takeaway
Doctors can use certain markers in breast cancer to better understand how likely a patient is to stay healthy after treatment.
Methodology
The study assessed invasion and proliferation markers in tumor tissue extracts and compared their prognostic impact on disease-free and overall survival.
Participant Demographics
Node-negative breast cancer patients without adjuvant systemic therapy.
Statistical Information
P-Value
P < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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