Topical Sodium Cromoglicate Reduces Itch and Flare from Histamine
Author Information
Author(s): Edwards Alan M, Stevens Michael T, Church Martin K
Primary Institution: The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Newport.
Hypothesis
SCG will have a similar effect on histamine-induced itch and flare as that demonstrated by nedocromil sodium.
Conclusion
Topically applied SCG significantly reduced the itch and flare caused by intradermal histamine, especially in atopic subjects.
Supporting Evidence
- SCG significantly reduced the severity of itch and flare when delivered by iontophoresis.
- Trend analysis showed increasing effect on itch with increased concentrations of SCG.
- There were no effects on wheal or blood flux.
Takeaway
This study found that a cream with sodium cromoglicate can help make itchy skin feel better, especially for people with allergies.
Methodology
The study involved 35 healthy volunteers who received sodium cromoglicate through iontophoresis and topical application, followed by histamine challenges to measure itch and flare responses.
Potential Biases
Potential conflicts of interest due to authors' affiliations with manufacturers of the tested product.
Limitations
The sample size was small, and the results may not be generalizable to all populations.
Participant Demographics
35 healthy volunteers (15 non-atopic and 20 atopic).
Statistical Information
P-Value
0.0045
Confidence Interval
(3.87, 17.57)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website