A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C
2000
New Insights into Mitomycin C Activation
publication
Author Information
Author(s): Joseph P, Jaiswal A K
Primary Institution: Department of Pharmacology, Baylor College of Medicine
Hypothesis
NQO1 plays only a minor role in the metabolic activation of mitomycin C.
Conclusion
A unique cytosolic activity, distinct from NQO1, is primarily responsible for the activation of mitomycin C.
Supporting Evidence
- NQO1 may play only a minor role in metabolic activation of mitomycin C.
- Cytosolic fractions from NQO1–/– mice showed similar DNA cross-linking upon exposure to mitomycin C as NQO1+/+ mice.
Takeaway
This study found that a special activity in cells helps activate a cancer drug called mitomycin C, and it's not just the previously thought enzyme NQO1 that does this.
Methodology
Cellular and animal models were used to study the activation of mitomycin C.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website