Effects of Fas-mediated liver cell apoptosis on liver cancer in mice
Author Information
Author(s): Hara A, Yoshimi N, Yamada Y, Matsunaga K, Kawabata K, Sugie S, Mori H
Primary Institution: Gifu University School of Medicine
Hypothesis
The study investigates the effect of Fas-mediated liver cell apoptosis on diethylnitrosamine-induced hepatocarcinogenesis in mice.
Conclusion
Fas-mediated liver cell apoptosis has a biphasic effect on hepatocarcinogenesis, with high doses reducing tumor incidence and low doses promoting tumor growth.
Supporting Evidence
- High dose anti-Fas antibody reduced the incidence of liver cell tumors in DEN-treated mice.
- Low dose anti-Fas antibody promoted the number of large-sized liver cell adenomas and hepatocellular carcinomas.
Takeaway
This study shows that giving a high dose of a specific antibody can help prevent liver cancer in mice, while a low dose can actually make it worse.
Methodology
The study involved treating 15-day-old male C3H/HeJ mice with diethylnitrosamine and administering different doses of anti-Fas antibody to observe effects on liver tumors.
Participant Demographics
15-day-old male C3H/HeJ mice
Digital Object Identifier (DOI)
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