HMGB-1 as a Diagnostic Marker for Acute Appendicitis
Author Information
Author(s): Yavuz Albayrak, Ayse Albayrak, Muhammet Celik, Ibrahim Gelincik, Ismail Demiryılmaz, Rahsan Yildirim, Bunyami Ozogul
Primary Institution: Erzurum Region Education and Research Hospital, Turkey
Hypothesis
High Mobility Group Box Protein-1 (HMGB-1) could be a good candidate to aid in the diagnosis of acute appendicitis in patients with normal white blood cell counts.
Conclusion
Higher levels of HMGB-1 in acute appendicitis patients compared to healthy individuals suggest that HMGB-1 may be useful for diagnosis, especially in those with normal WBC counts.
Supporting Evidence
- HMGB-1 levels were significantly higher in acute appendicitis patients compared to healthy controls.
- The average HMGB-1 level in patients with acute appendicitis was 36.92 ng/ml.
- The study found that HMGB-1 could help diagnose appendicitis in patients with normal WBC counts.
Takeaway
Doctors can use a blood test for HMGB-1 to help figure out if someone has appendicitis, even if their white blood cell count looks normal.
Methodology
The study included 60 patients with acute appendicitis and 20 healthy controls, measuring HMGB-1 levels and comparing them across groups.
Limitations
The study excluded patients with various health conditions, which may limit the generalizability of the findings.
Participant Demographics
60 patients (36 male, 24 female) with acute appendicitis and 20 healthy controls (12 male, 8 female).
Statistical Information
P-Value
0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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